Oprozomib
3
Destiny
9
Soul Urge
3
Personality
Oprozomib (codenamed ONX 0912 and PR-047) is an orally active second-generation proteasome inhibitor developed by Proteolix, which was acquired by Onyx Pharmaceuticals, an Amgen subsidiary, in 2009. It selectively inhibits chymotrypsin-like activity of both the constitutive proteasome (PSMB5) and immunoproteasome (LMP7). It is being investigated for the treatment of hematologic malignancies, specifically, multiple myeloma, with Phase 1b studies ongoing (as of February 16, 2016). Being an epoxyketone derivative, oprozomib is structurally related to carfilzomib and has the added benefit of being orally bioavailable. Like carfilzomib, it is active against bortezomib-resistant multiple myeloma cells. Oprozomib was granted orphan drug status for the treatment of Waldenström's macroglobulinaemia and multiple myeloma in 2014.
Destiny 3 — The Creator
The number of creative expression, communication, and joy. Destiny 3 subjects bring beauty, story, and warmth into the world — their name resonates with the frequency of art and human connection.
Explore Life Path 3 in depth →Numerology profile
Destiny Number
3 — The Creator
Soul Urge
9 — The Humanitarian
Personality
3 — The Creator
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